News

Liverpool Neuroscience Day 2019

LND2019 – June 14 2019

Speakers & Programme Posters Registration Venue

Liverpool Neuroscience Group will host the 6th Liverpool Neuroscience Day on Friday 14th June 2019.


The aim of Liverpool Neuroscience Group is to explore the breadth and depth of research activity in brain and behavioural sciences across the city and beyond. The meetings foster collaborations and celebrate neuroscience research, and have proven to be an excellent opportunity for the many local neuroscience groups and researchers to showcase their findings, share ideas and network.

For questions about the event please or email: admin@lng.org.uk


Speakers

⇑ Top


Posters

.

⇑ Top


Registration

⇑ Top


Venue

James Parsons – Lower Lecture Theatre
LJMU, Byrom Street, Liverpool, L3 3AF
Venue Details Coming Soon

⇑ Top

Visual Properties Driving Visual Preference (VPDVP)

The 5thedition of the Visual Properties Driving Visual Preference (VPDVP) workshop will take place at on 13-14 June 2019. We are happy to confirm the following keynote presentations.

Keynote speakers:

Johan Wagemans (University of Leuven, Belgium)

Chris McManus (UCL, UK)

Edward Vessel (Max Planck Institute for Empirical Aesthetics, Germany)

Since 2015, VPDVP has provided the forum to explore preference for a variety of visual properties, including symmetry, fractals, natural statistics and smooth curvature. More information on previous editions can be found here: www.bertamini.org/lab/vpdvp.html

Whilst keeping the same format (i.e. presentations and round table discussion), this year we explore empirical aesthetics and visual preference in relation to individual differences, mental health and wellbeing. We value the use of multidisciplinary approaches to address these questions; therefore, professionals and collaborators working in visual arts, architecture and design are encouraged to attend the workshop.

In order to allow fruitful discussions, we prefer keeping the number of attendees low (40-50 people). To enquire about space and register please fill in the attached form and send it to vpdvpworkshop@gmail.com

If you would like to present your work, please submit an abstract (300 words limit)by the 1stApril 2019 5pm UK timeto: vpdvpworkshop@gmail.com All abstracts will be reviewed.

Sponsored by the International Association of Empirical Aesthetics (IAEA)

science-of-aesthetics.org/

Organizers:

Marco Bertamini, Letizia Palumbo

GSTT: Molecular Insights into Parkinson’s Disease: Deciphering the Mechanism of Parkin E3 Ligase and PINK1 Kinase

Genomes, Systems and Therapeutic Targeting Seminar Series

Hosts:
Sonia Rocha (Sonia.Rocha@liverpool.ac.uk)
Caroline Dart (C.Dart@liverpool.ac.uk)

Speaker:
Dr Atul Kumar, Dundee University

Parkinson’s disease (PD) is a neurodegenerative disorder with severe motor and non-motor symptoms. Mutations on several genes associated with various structural and functional components of neurons cause loss of neurons which results in PD. However, two genes PARK2 and PARK6 are found most frequently mutated causing more than 50% of the familial form of the disease. PARK2 gene encodes an E3 ubiquitin ligase Parkin, and PARK6 encodes PTEN-induced Kinase 1 (PINK1). Parkin is an auto-inhibited enzyme mediated by its ubiquitin like (UBL) domain. During stress condition, PINK1 is stabilised on mitochondria and phosphorylates Ser65 on UBL domain of Parkin and ubiquitin. Phosphorylation of Parkin and ubiquitin results in fully active Parkin which clears the damaged mitochondria, however, underlying molecular mechanism of PINK1 and Parkin signalling is poorly understood. I have determined human Parkin structures in both in-active state (apo-Parkin) & active state (phospho-mimic Parkin & in complex with phospho-ubiquitin (pUb)). My research on Parkin reveals how Ubl domain cause inhibition, and how Parkin is allosterically activated by pUb binding. My research reveals an intriguing mechanism of catalysis of Parkin E3 ubiquitin ligase. I have also solved the first crystal structure of PINK1 and identified a unique insertion in the kinase domain responsible for specific recognition of ubiquitin/UBL domain of Parkin. Mapping of mutations on PINK1 and Parkin structures suggests that mutations are present in important functional regions perturbing function of these enzymes and cause Parkinson’s. The study provides molecular rationale for therapeutics purpose, and lays foundation of future research towards identifying key enzymes involved in phospho-ubiquitin signalling along with establishing the role of other genes associated with the disease.

Location:
Lecture Theatre 1, Life Sciences Building, Crown Street, L69 7ZB

PRI: Research & Publication Day

The Pain Research Institute invites all researchers, clinicians and students in Liverpool & the Northwest, with an interest in pain research to attend the PRI Research & Publication Day.

To register, and/or volunteer to present at the event – contact: Hayley McCullough

CANS Meeting: Nicola Jones

Cognitive and Affective Neuroscience @ LJMU. Speaker: Nicola Jones

Nicola’s interests include learning, memory and attention, and how these processes are represented behaviourally and at a neural level in both typical and atypical populations. Her PhD research was focused on investigating the effects of glucoregulation on memory and face recognition in older adults.

Sutcliffe Kerr Day 2019

The Walton Centre & Liverpool Neursocience Group together present an extended programme of Clinical Neuroscience research presentations, followed by the annual Sutcliffe Kerr lecture, given this year by Professor Julie Williams CBE – director of the Dementia Research Institute at Cardiff University, and Chief Scientific Advisor to the Welsh Government.

Click Here For Registration

For more information please email Medical_Education@thewaltoncentre.nhs.uk


Agenda

LUNCH / REGISTRATION 12pm-12.45pm
common room
Lunchtime Lecture: ‘The immune system and the brain’ Dr David Hunt
Wellcome Trust Clinician Scientist
Honorary Consultant Neurologist
Edinburgh University
12.45pm-1.30pm
Seminar 1: Lecture and case presentation Professor Charles Leek
Dean of the Institute of Life Health Sciences
University of Liverpool
1.30pm – 2.30pm
Break 2.30pm-2.45pm
common room
Seminar 2: Lecture and case presentation Professor Carolyn Young MD, FRCP
Consultant Neurologist
Honorary Professor of Neurology
Walton Centre NHS Trust 
2.45pm – 3.45pm
Seminar 3: Lecture and case presentation Dr Yasir Abbasi
Consultant Psychiatrist
Merseycare NHS Trust
3.45pm – 4.45pm
TEA / REGISTRATION (SKL) 4.45pm – 5.30pm
common room
Sutcliffe Kerr Lecture: ‘Getting ‘a head’ in Neuroscience’ Professor Julie Williams CBE
Neurogeneticist
Chief Scientific Adviser for Wales
5.30pm-6.30pm

 

 


Professor Julie Williams

Now a senior figure in the field of Alzheimer’s disease (AD) research, Julie graduated from the University of Wales Institute of Science & Technology (BSc, 1978), later completing her PhD (1987) before taking up a Research Assistant post in the Department of Psychological Medicine, University of Wales College of Medicine.

Quickly progressing to Professorial level, by virtue of authoring a number of key publications, and successfully winning highly contested research funding, Julie remains a Professor and Head of Neurodegeneration at the MRC CNGG, School of Medicine, Cardiff University.

During this time Julie served on the MRC Neuroscience and Mental Health Board and the Scientific Advisory Board of Alzheimer’s Research UK.

She became Chief Scientific Advisor to Alzheimer’s Research UK (2008), using this position to broaden science funding options, increase research capacity and training, and has actively campaigned to keep the importance of dementia research on the National agenda.

She has advised UK and Welsh Governments on dementia policy, was Dean of Research at the School of Medicine, Cardiff University, and a member of the Senior Faculty of NISCHR.

Honoured as a commander of the British Empire (CBE) in the 2012 Queen’s Jubilee Birthday Honour list, Julie was subsequently (2013) appointed Chief Scientific Advisor to the Welsh Government (tenure completed Sept. 2017) and developed the important science package ‘Ser Cymru 2’, later adopted as policy.

Julie’s research focuses upon identifying and understanding genes which alter the risk of complex psychological and neurodegenerative disorders, with a particular interest in deciphering the genetics of AD.

A pioneer of working collaboratively, having recognised early the complexity of AD genetics, and having participated in many world-wide, powerful consortia, the consortium she leads, GERAD (Genetic and Environmental Risk in Alzheimer’s Disease), plays a dominant role in the field, focusing on developing larger, more powerful studies.

JW has become a leader within the IGAP genetics consortium, which incorporates over 150 scientists world-wide, with access to a 90,000 strong cohort, mega-meta analyses of which have identified at least 13 new susceptibility genes for AD.

Her research has encompassed GWAS, sequencing, large exome chip association studies, and cross disease complex phenotypic and statistical analyses.

TIME magazine rated two of Julie’s research papers from 2005 and 2009 as within the top 10 breakthroughs of those years.

Currently Julie has a leading role in, and receives research funding from an MRC programme grant, the Dementia’s Platform UK (MRC), Alzheimer’s Research UK (ARUK), the Joint Programme for Neurodegenerative Disease Research (JPND), Centre for Aging and Dementia Research (Welsh Government), European Prevention of Alzheimer’s Disease Consortium (Innovative Medicines Initiative), Brains for Dementia Research (BDR), and the Moondance Charitable Foundation among others.

In 2017, Julie successfully led a bid for Cardiff University to be part of the £250m UK Dementia Research Institute funded by the MRC, ARUK and AS (Alzheimer’s Society).

Sheffield Neurosoc: The Brain in Flux Conference

Annual one day conference organised by Sheffield Neurosoc, in affiliation with Sheffield Medical School – focusing on topics such as learning and sleep.

Post Abstract Deadline: 14th January 2019.

Undergraduate students, postgraduate students, junior doctors and researchers are welcome to submit abstracts.

Further details from shefneurosco@gmail.com

Hope Psychology Seminar, Dr. Lucia Garrido: Multisensory representations of faces and voices

VENUE: Hope Park Sports Building Room 106

Abstract: Faces and voices convey much of the non-verbal information that we use when communicating with other people. We look at faces and listen to voices to recognise others, understand how they are feeling, and decide how to act. Recent research in my lab aims to investigate whether there are similar coding mechanisms to represent faces and voices, and whether there are brain regions that integrate this information across the visual and auditory modalities. I will focus on three main studies during my talk. In a first study (Kuhn et al., 2017), we found highly similar representations of emotion across facial and vocal stimuli, which suggest similar or shared coding mechanisms for emotion that may act independently of modality. In a second study, we used fMRI and found that a region of the posterior STS seems to contain modality-general representations of familiar people that can be similarly driven by faces and voices. In the final part of my talk, I will describe our recent attempts to shed light on the type of information that is represented about familiar people in different face- and voice-responsive brain regions.

All are welcome, light refreshments are served afterwards.

CANS Meeting: Samatha Brooks

Cognitive and Affective Neuroscience research group meeting.

Speaker: Dr Samantha Brooks.

Title: Learning from the neural correlates of Anorexia Nervosa about how we might treat Substance Use Disorder.

The rising trend of internationally competitive research into the cognitive control of impulsivity reflects the importance of examining the neural mechanisms of impulse control.  The rising trend might be due to impulse control deficits contributing substantially to the increase in serious mental and physical disorders that are prevalent globally. Impulse control, the tendency to prevent actions that are harmful to self and others, is fostered by prefrontal cortex executive functions – such as working memory (WM) – interacting with limbic processes.  This interaction is referred to in a growing body of publications by terms like cognitive control, cognitive inhibition, affect regulation, self-regulation, top-down control, and cognitive–emotion interaction. Against this background, I describe the novel international approaches my collaborators and I have taken to tackle this important issue, that has led to over 70 publications examining cognitive control from the perspective of anorexia nervosa through to substance use disorder.