14-24 – Translating a Novel Schema Memory Paradigm to Advance Understanding of Memory Processes

Memories are stronger when connected to existing knowledge or schemas. Research on schema formation in animal models has provided valuable insights into the neurobiology underlying memory consolidation (Tse et al., 2007; 2011; Bethus et al., 2012; Wang et al., 2012). However, a critical gap remains due to the lack of a translational paradigm for human studies. This project aims to address this gap by adapting a novel schema memory paradigm from animals to humans.
In addition, spatial navigation has also been identified as a potential cognitive marker for preclinical Alzheimer’s disease (AD). This research seeks to develop a translatable behavioural model from animals to humans to detect AD-related changes effectively.
We have designed a computer-based task simulating a virtual shopping mall where participants navigate and learn the locations of various items through a paired-associate task. The task aims to measure spatial navigation abilities in older adults and explore schema formation and the timing of memory consolidation. Participants in the experimental group will navigate a consistent map where items and locations remain the same, while those in the control group will navigate an inconsistent map with varying items and locations.
The study will involve two groups: young adults (18–30; n=30) and healthy elderly participants (+60; n=30). We hypothesize that the experimental group will perform better and learn new paired associates faster than the control group, based on the schema hypothesis that a consistent schema aids in learning. We also expect fewer errors in the experimental group when navigating the inconsistent map condition.